Wham is suitable for paired-conclusion Illumina libraries with regular insert dimensions (~300bp-500bp). Wham integrates mate-pair mapping, break up read through mapping, delicate-clipping, alternative alignment and consensus sequence dependent evidence to forecast SV breakpoints with single-nucleotide accuracy. Wham generates a put together pileup

Wham clusters every one of the candidate breakpoints and rounds their positions to the nearest tenth foundation pair. The situation with the very best examine help is noted. If the delicate-clipped consensus sequence can be aligned on the putative breakpoint region utilizing the Smith-Waterman algorithm, the breakpoint is further more refined to th